TFcancer, a manually curated database, features in comprehensive annotations of TFs in human cancers. Currently, TFcancer covers 3136 associations between 461 TFs and 33 cancers by manual review of 1843 published papers. TFcancer mainly focused on the influence of transcription factors on four dimensions in cancer: dysexpression, molecular alteration, regulatory relationships between TFs and other genes, last but not least, cancer process and signaling pathways. Users can retrieve results by searching specific TF names or cancer types.