EnhancerDB
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Enhancers that regulate MTHFR[ENSG00000177000.6]
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Chrom. Start End Enhancer ID TSS of gene Distance between enhancer and TSS Tissues that enhancer appears More
chr1 11791882 11792060 vista365 11866977 74917
VISTA
chr1 11797729 11803253 enh61791 11866977 63724
Brain (SK-N-SH) Esophagus Peripheral Blood (MM.1S) Blood (T-cell) Stomach
chr1 11798209 11798600 vista366 11866977 68377
VISTA
chr1 11798918 11799121 vista367 11866977 67856
VISTA
chr1 11841016 11841080 vista368 11866977 25897
VISTA
chr1 11843265 11847435 enh11502 11866977 19542
Stomach Placenta Heart
chr1 11847301 11852413 vista15 11866977 14564
VISTA
chr1 11871185 11875375 enh60091 11866977 4208
Blood (OCI-LY7)
chr1 11906876 11908666 vista16 11866977 39899
VISTA
chr1 11932414 11936855 enh63993 11866977 65437
Heart
chr1 11938105 11949624 enh42885 11866977 71128
Bone Marrow (K562) Liver (HepG2) Stomach Thyroid Muscle (Myotube) Heart
chr1 11940877 11944112 vista17 11866977 73900
VISTA
chr1 11942925 11943217 vista369 11866977 75948
VISTA
chr1 11945528 11949490 vista18 11866977 78551
VISTA
chr1 11954863 11954882 vista370 11866977 87886
VISTA
chr1 11958523 11963715 enh65 11866977 91546
Blood (OCI-LY7) Blood (Karpas-422) Lung (PC-9)
chr1 11965155 11977072 enh66 11866977 98178
Liver (HepG2) Prostate (RWPE1) Bone (Osteoblast) Blood (OCI-LY7) Colon (HCT116) Blood (Karpas-422) Pancreas (Panc1) Uterus
Transcript facotrs that regulate MTHFR[ENSG00000177000.6]
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Chrom. Start End TF name Source Predicted site? Tissue TSS of gene Distance between TFBS and gene id More
chr1 11871188 11871199 EBF1 JASPAR yes 11866977 4211 26786195
chr1 11871193 11871214 ZNF263 JASPAR yes 11866977 4216 26786196
chr1 11871215 11871229 MTF1 JASPAR yes 11866977 4238 26786197
chr1 11871219 11871229 SREBF1 JASPAR yes 11866977 4242 26786198
chr1 11871219 11871229 SREBF2 JASPAR yes 11866977 4242 26786199
chr1 11871240 11871259 PAX5 JASPAR yes 11866977 4263 26786200
chr1 11871244 11871255 NFE2L2 JASPAR yes 11866977 4267 26786201
chr1 11871294 11871304 RUNX3 JASPAR yes 11866977 4317 26786202
chr1 11871295 11871304 RUNX2 JASPAR yes 11866977 4318 26786203
chr1 11871326 11871336 HOXA13 JASPAR yes 11866977 4349 26786204
chr1 11871326 11871336 HOXB13 JASPAR yes 11866977 4349 26786205
chr1 11871326 11871336 HOXD13 JASPAR yes 11866977 4349 26786206
chr1 11871326 11871337 HOXA10 JASPAR yes 11866977 4349 26786207
chr1 11871327 11871336 CDX1 JASPAR yes 11866977 4350 26786208
chr1 11871327 11871338 CDX2 JASPAR yes 11866977 4350 26786209
chr1 11871336 11871348 MEF2B JASPAR yes 11866977 4359 26786210
chr1 11871338 11871342 TEAD2 TRANSFAC yes 11866977 4361 26786211
chr1 11871338 11871348 HESX1 JASPAR yes 11866977 4361 26786212
chr1 11871339 11871347 DLX6 JASPAR yes 11866977 4362 26786213
chr1 11871339 11871347 MSX2 JASPAR yes 11866977 4362 26786214
chr1 11871339 11871353 POU1F1 JASPAR yes 11866977 4362 26786215
chr1 11871340 11871353 POU3F3 JASPAR yes 11866977 4363 26786216
chr1 11871343 11871349 NFIC JASPAR yes 11866977 4366 26786217
chr1 11871396 11871410 POU1F1 JASPAR yes 11866977 4419 26786218
chr1 11871397 11871409 POU3F2 JASPAR yes 11866977 4420 26786219
chr1 11871397 11871410 POU3F3 JASPAR yes 11866977 4420 26786220
chr1 11871398 11871410 POU2F1 JASPAR yes 11866977 4421 26786221
chr1 11871435 11871456 IRF1 JASPAR yes 11866977 4458 26786222
chr1 11871440 11871455 FOXP1 JASPAR yes 11866977 4463 26786223
chr1 11871441 11871456 FOXP1 JASPAR yes 11866977 4464 26786224
chr1 11871442 11871457 FOXP1 JASPAR yes 11866977 4465 26786225
chr1 11871443 11871458 FOXP1 JASPAR yes 11866977 4466 26786226
chr1 11871444 11871459 FOXP1 JASPAR yes 11866977 4467 26786227
chr1 11871463 11871478 IRF9 JASPAR yes 11866977 4486 26786228
chr1 11871470 11871489 RFX2 JASPAR yes 11866977 4493 26786229
chr1 11871474 11871490 RFX5 JASPAR yes 11866977 4497 26786230
chr1 11871505 11871515 SREBF1 JASPAR yes 11866977 4528 26786231
chr1 11871507 11871524 ESR1 JASPAR yes 11866977 4530 26786232
chr1 11871582 11871595 SMAD2 JASPAR yes 11866977 4605 26786233
chr1 11871599 11871614 MEF2A JASPAR yes 11866977 4622 26786234
chr1 11871600 11871615 MEF2C JASPAR yes 11866977 4623 26786235
chr1 11871607 11871622 MEF2A JASPAR yes 11866977 4630 26786236
chr1 11871608 11871623 MEF2C JASPAR yes 11866977 4631 26786237
chr1 11871609 11871621 MEF2A JASPAR yes 11866977 4632 26786238
chr1 11871609 11871621 MEF2B JASPAR yes 11866977 4632 26786239
chr1 11871609 11871621 MEF2D JASPAR yes 11866977 4632 26786240
chr1 11871611 11871615 YY1 TRANSFAC yes 11866977 4634 26786241
chr1 11871632 11871644 YY1 JASPAR yes 11866977 4655 26786242
chr1 11871639 11871659 PPARG JASPAR yes 11866977 4662 26786243
chr1 11871642 11871662 ESR1 JASPAR yes 11866977 4665 26786244
chr1 11871643 11871647 ESR1 TRANSFAC yes 11866977 4666 26786245
chr1 11871654 11871672 RARA JASPAR yes 11866977 4677 26786246
chr1 11871669 11871679 SREBF1 JASPAR yes 11866977 4692 26786247
chr1 11871669 11871679 SREBF2 JASPAR yes 11866977 4692 26786248
chr1 11871679 11871684 SP1 TRANSFAC yes 11866977 4702 26786249
chr1 11871682 11871696 PLAG1 JASPAR yes 11866977 4705 26786250
chr1 11871687 11871694 E2F1 TRANSFAC yes 11866977 4710 26786251
chr1 11871761 11871765 YY1 TRANSFAC yes 11866977 4784 26786252
chr1 11871768 11871778 SREBF2 JASPAR yes 11866977 4791 26786253
chr1 11871770 11871775 USF2 TRANSFAC yes 11866977 4793 26786254
chr1 11871776 11871783 SPIB JASPAR yes 11866977 4799 26786255
chr1 11871782 11871798 SOX4 JASPAR yes 11866977 4805 26786256
chr1 11871790 11871800 EMX1 JASPAR yes 11866977 4813 26786257
chr1 11871790 11871800 EVX1 JASPAR yes 11866977 4813 26786258
chr1 11871790 11871800 EVX2 JASPAR yes 11866977 4813 26786259
chr1 11871790 11871800 HOXA2 JASPAR yes 11866977 4813 26786260
chr1 11871790 11871800 HOXB2 JASPAR yes 11866977 4813 26786261
chr1 11871790 11871800 HOXB3 JASPAR yes 11866977 4813 26786262
chr1 11871790 11871800 NOTO JASPAR yes 11866977 4813 26786263
chr1 11871793 11871797 YY1 TRANSFAC yes 11866977 4816 26786264
chr1 11871802 11871817 AR JASPAR yes 11866977 4825 26786265
chr1 11871805 11871825 ESR1 JASPAR yes 11866977 4828 26786266
chr1 11871853 11871857 NFE TRANSFAC yes 11866977 4876 26786267
chr1 11871856 11871869 POU2F2 JASPAR yes 11866977 4879 26786268
chr1 11871857 11871870 POU3F3 JASPAR yes 11866977 4880 26786269
chr1 11871858 11871862 YY1 TRANSFAC yes 11866977 4881 26786270
chr1 11871858 11871870 POU2F1 JASPAR yes 11866977 4881 26786271
chr1 11871892 11871904 FOXC2 JASPAR yes 11866977 4915 26786272
chr1 11871892 11871906 FOXF2 JASPAR yes 11866977 4915 26786273
chr1 11871893 11871901 FOXD1 JASPAR yes 11866977 4916 26786274
chr1 11871893 11871901 FOXG1 JASPAR yes 11866977 4916 26786275
chr1 11871893 11871901 FOXO3 JASPAR yes 11866977 4916 26786276
chr1 11871894 11871901 FOXD2 JASPAR yes 11866977 4917 26786277
chr1 11871894 11871901 FOXI1 JASPAR yes 11866977 4917 26786278
chr1 11871894 11871901 FOXL1 JASPAR yes 11866977 4917 26786279
chr1 11871894 11871901 FOXO4 JASPAR yes 11866977 4917 26786280
chr1 11871894 11871901 FOXO6 JASPAR yes 11866977 4917 26786281
chr1 11871894 11871901 FOXP3 JASPAR yes 11866977 4917 26786282
chr1 11871902 11871918 SOX4 JASPAR yes 11866977 4925 26786283
chr1 11871903 11871918 SOX21 JASPAR yes 11866977 4926 26786284
chr1 11871911 11871915 YY1 TRANSFAC yes 11866977 4934 26786285
chr1 11871946 11871954 HOXA5 JASPAR yes 11866977 4969 26786286
chr1 11871948 11871962 POU1F1 JASPAR yes 11866977 4971 26786287
chr1 11871949 11871961 POU3F1 JASPAR yes 11866977 4972 26786288
chr1 11871949 11871961 POU3F2 JASPAR yes 11866977 4972 26786289
chr1 11871949 11871962 POU3F3 JASPAR yes 11866977 4972 26786290
chr1 11871950 11871960 NFATC3 JASPAR yes 11866977 4973 26786291
chr1 11871950 11871962 POU2F1 JASPAR yes 11866977 4973 26786292
chr1 11871951 11871960 POU3F4 JASPAR yes 11866977 4974 26786293
chr1 11871951 11871960 POU5F1B JASPAR yes 11866977 4974 26786294
chr1 11871962 11871966 YY1 TRANSFAC yes 11866977 4985 26786295
chr1 11871975 11871990 SOX21 JASPAR yes 11866977 4998 26786296
SNPs associated with MTHFR[ENSG00000177000.6], confirmed by eQTL
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Chrom. Position dbSNP ID Reference Allele Alternative Allele Distance between TSS and SNP Tissue q Value id More
chr1 11899033 rs1023252 G T 32056 Esophagus 0.00206713 81187
chr1 11899033 rs1023252 G T 32056 Pancreas 0.000649405 81187
chr1 11899033 rs1023252 G T 32056 Breast 0.000241605 81187
chr1 11851003 rs3818762 G C 0 Spleen 0.000250783 80996
chr1 11899033 rs1023252 G T 32056 Uterus 0.175876 81187
chr1 11851003 rs3818762 G C 0 Lung 8.95085e-08 80996
chr1 11851003 rs3818762 G C 0 Adrenal 0.00439589 80996
Details of MTHFR[ENSG00000177000.6]
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Genomic Location chr1:11845780-11866977[-]
TSS 11866977
Gene Name MTHFR
Ensembl ID ENSG00000177000.6
ENTREZID 4524
Uniprot
Q8IU67
Q59GJ6
P42898
Protein Name
MTHF reductase
Methylenetetrahydrofolate reductase
Expression levels of MTHFR[ENSG00000177000.6]
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