EnhancerDB
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Enhancers that regulate SMAD6[ENSG00000137834.10]
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Chrom. Start End Enhancer ID TSS of gene Distance between enhancer and TSS Tissues that enhancer appears More
chr15 66901685 66918810 enh16250 66994566 75756
Bone Marrow (K562) Prostate (PC-3) Cervix (HeLa-S3) Epithelial (MCF-7) Large Intestine Prostate (RWPE1) Esophagus Astrocyte Ovary Bone (Osteoblast) Stomach Muscle (A673) Placenta Colon (HCT116) Uterus Pancreas Pancreas (Panc1) Muscle (Myotube) Neural Stem Cells (H9) Heart
chr15 66910064 66910181 vista20392 66994566 84385
VISTA
chr15 66914097 66914368 vista20393 66994566 80198
VISTA
chr15 66919405 66957192 enh16251 66994566 37374
Bone Marrow (K562) Brain (SK-N-MC) Astrocyte Embryonic Stem Cell Line (H1-hESC) Uterus Epithelial (MCF-7) Stomach Brain (SK-N-SH) Ovary Bone (Osteoblast) Peripheral Blood (MM.1S) Pancreas (Panc1) Neural Stem Cells (H9) Prostate (PC-3) Cervix (HeLa-S3) Large Intestine Esophagus Placenta Spleen Muscle (Myotube) Liver (HepG2) Prostate (RWPE1) Muscle (A673) Heart
chr15 66923146 66923585 vista20394 66994566 70981
VISTA
chr15 66960486 66968445 enh52053 66994566 26121
Bone Marrow (K562) Skin (Keratinocyte) Prostate (PC-3) Large Intestine Blood (OCI-LY7) Colon (HCT116) Lung (PC-9) Neural Stem Cells (H9) Epithelial (MCF-7)
chr15 66965990 66966192 vista20395 66994566 28374
VISTA
chr15 66967847 66967978 vista20396 66994566 26588
VISTA
chr15 66969274 66978715 enh16252 66994566 15851
Bone Marrow (K562) Brain (SK-N-SH) Large Intestine Blood (OCI-LY7) Placenta Peripheral Blood (MM.1S) Heart
chr15 66971406 66971462 vista20397 66994566 23104
VISTA
chr15 66972187 66972410 vista20398 66994566 22156
VISTA
chr15 66979265 66987638 enh47880 66994566 6928
Bone Marrow (K562) Thymus Blood (OCI-LY7) Blood (T-cell) Stomach
chr15 66985415 66985517 vista20399 66994566 9049
VISTA
chr15 66993287 66993569 vista20400 66994566 997
VISTA
chr15 67001955 67008735 enh102523 66994566 7389
Peripheral Blood (MM.1S) Bone (Osteoblast)
chr15 67009025 67073235 enh16253 66994566 14459
Brain (SK-N-MC) Liver Astrocyte Colon (HCT116) Embryonic Stem Cell Line (H1-hESC) Pancreas Uterus Epithelial (MCF-7) Kidney Stomach Brain (SK-N-SH) Ovary Bone (Osteoblast) Thyroid Neural Stem Cells (H9) Prostate (PC-3) Cervix (HeLa-S3) Large Intestine Esophagus Placenta Lung (PC-9) Breast Muscle (Myoblast) Spleen Muscle (Myotube) Liver (HepG2) Prostate (RWPE1) Muscle (A673) Heart
chr15 67076011 67084255 enh16254 66994566 81445
Large Intestine Esophagus Astrocyte Bone (Osteoblast) Muscle (A673) Placenta Stomach
chr15 67077622 67077754 vista20401 66994566 83056
VISTA
chr15 67086305 67100155 enh16255 66994566 91739
Bone Marrow (K562) Brain (SK-N-MC) Astrocyte Colon (HCT116) Adrenal Pancreas Uterus Epithelial (MCF-7) Kidney Stomach Brain (SK-N-SH) Ovary Bone (Osteoblast) Thyroid Pancreas (Panc1) Prostate (PC-3) Cervix (HeLa-S3) Large Intestine Esophagus Placenta Lung (PC-9) Breast Muscle (Myoblast) Spleen Muscle (Myotube) Liver (HepG2) Lung Muscle (A673) Heart
Transcript facotrs that regulate SMAD6[ENSG00000137834.10]
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Chrom. Start End TF name Source Predicted site? Tissue TSS of gene Distance between TFBS and gene id More
chr15 66992879 66993529 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1037 108148368
chr15 66992895 66993481 ZNF217 ENCODE Uniform TFBS no Epithelial (MCF-7) 66994566 1085 108148369
chr15 66992895 66993782 E2F1 UCSC Txn Factor no Conserved 66994566 784 108148370
chr15 66992896 66993556 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1010 108148371
chr15 66992905 66993429 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1137 108148372
chr15 66992913 66993489 ZBTB33 ENCODE Uniform TFBS no Lung (A549) 66994566 1077 108148373
chr15 66992919 66995000 POLR2A UCSC Txn Factor no Conserved 66994566 434 108148374
chr15 66992975 66993499 ZBTB33 ENCODE Uniform TFBS no Colon (HCT116) 66994566 1067 108148375
chr15 66993004 66993514 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1052 108148376
chr15 66993028 66993518 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1048 108148377
chr15 66993046 66993502 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1064 108148378
chr15 66993053 66993403 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1163 108148379
chr15 66993053 66993493 TCF7L2 ENCODE Uniform TFBS no Pancreas (Panc1) 66994566 1073 108148380
chr15 66993058 66993554 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1012 108148381
chr15 66993058 66993594 ZBTB33 ENCODE Uniform TFBS no Lung (A549) 66994566 972 108148382
chr15 66993063 66993310 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1256 108148383
chr15 66993082 66993546 ZBTB33 ENCODE Uniform TFBS no Colon (HCT116) 66994566 1020 108148384
chr15 66993083 66993539 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1027 108148385
chr15 66993089 66993545 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1021 108148386
chr15 66993090 66993560 TCF7L2 ENCODE Uniform TFBS no Pancreas (Panc1) 66994566 1006 108148387
chr15 66993095 66993405 ZNF217 ENCODE Uniform TFBS no Epithelial (MCF-7) 66994566 1161 108148388
chr15 66993102 66993412 ZBTB33 ENCODE Uniform TFBS no Lung (A549) 66994566 1154 108148389
chr15 66993102 66993506 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1060 108148390
chr15 66993116 66993440 ZZZ3 ENCODE Uniform TFBS no Blood (GM12878) 66994566 1126 108148391
chr15 66993118 66993518 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1048 108148392
chr15 66993130 66993409 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1157 108148393
chr15 66993139 66993455 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1111 108148394
chr15 66993139 66993479 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1087 108148395
chr15 66993142 66993538 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1028 108148396
chr15 66993145 66993489 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1077 108148397
chr15 66993146 66993453 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1113 108148398
chr15 66993147 66993483 ZNF143 ENCODE Uniform TFBS no Embryonic Stem Cell Line (H1-hESC) 66994566 1083 108148399
chr15 66993160 66993484 ZNF143 ENCODE Uniform TFBS no Embryonic Stem Cell Line (H1-hESC) 66994566 1082 108148400
chr15 66993163 66993453 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1113 108148401
chr15 66993167 66993427 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1139 108148402
chr15 66993168 66993528 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1038 108148403
chr15 66993174 66993482 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1084 108148404
chr15 66993180 66993504 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1062 108148405
chr15 66993183 66993619 ZZZ3 ENCODE Uniform TFBS no Blood (GM12878) 66994566 947 108148406
chr15 66993187 66993527 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1039 108148407
chr15 66993189 66993559 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 1007 108148408
chr15 66993190 66993546 TAF1 ENCODE Uniform TFBS no Brain (SK-N-SH) 66994566 1020 108148409
chr15 66993206 66993476 ZBTB33 ENCODE Uniform TFBS no Colon (HCT116) 66994566 1090 108148410
chr15 66993214 66993464 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1102 108148411
chr15 66993215 66993340 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1226 108148412
chr15 66993224 66993442 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1124 108148413
chr15 66993246 66993417 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 1149 108148414
chr15 66993253 66993414 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1152 108148415
chr15 66993288 66993292 ESR1 TRANSFAC yes 66994566 1274 70545038
chr15 66993291 66993854 TCF7L2 UCSC Txn Factor no Conserved 66994566 712 108148416
chr15 66993292 66993306 EBF1 JASPAR yes 66994566 1260 70545039
chr15 66993293 66993304 EBF1 JASPAR yes 66994566 1262 70545040
chr15 66993301 66993677 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 889 108148417
chr15 66993303 66993833 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 733 108148418
chr15 66993307 66993312 SP1 TRANSFAC yes 66994566 1254 70545041
chr15 66993308 66993320 TFAP2A JASPAR yes 66994566 1246 70545042
chr15 66993309 66993765 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 801 108148419
chr15 66993311 66993322 NRF1 JASPAR yes 66994566 1244 70545043
chr15 66993314 66993784 TCF7L2 ENCODE Uniform TFBS no Pancreas (Panc1) 66994566 782 108148420
chr15 66993316 66993330 ZIC1 JASPAR yes 66994566 1236 70545044
chr15 66993316 66993331 ZIC4 JASPAR yes 66994566 1235 70545045
chr15 66993321 66993817 ZNF217 ENCODE Uniform TFBS no Epithelial (MCF-7) 66994566 749 108148421
chr15 66993326 66993330 ESR1 TRANSFAC yes 66994566 1236 70545046
chr15 66993326 66993706 ZZZ3 ENCODE Uniform TFBS no Blood (GM12878) 66994566 860 108148422
chr15 66993328 66993416 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 1150 108148423
chr15 66993336 66993696 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 870 108148424
chr15 66993339 66993855 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 711 108148425
chr15 66993340 66993352 E2F1 JASPAR yes 66994566 1214 70545047
chr15 66993347 66993355 SP1 TRANSFAC yes 66994566 1211 70545048
chr15 66993347 66993362 TFAP2A JASPAR yes 66994566 1204 70545049
chr15 66993347 66993362 TFAP2C JASPAR yes 66994566 1204 70545050
chr15 66993347 66993887 ZBTB33 ENCODE Uniform TFBS no Lung (A549) 66994566 679 108148426
chr15 66993350 66993361 TFAP2A JASPAR yes 66994566 1205 70545051
chr15 66993350 66993362 TFAP2A JASPAR yes 66994566 1204 70545052
chr15 66993350 66993362 TFAP2B JASPAR yes 66994566 1204 70545053
chr15 66993350 66993362 TFAP2C JASPAR yes 66994566 1204 70545054
chr15 66993350 66993854 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 712 108148427
chr15 66993351 66993360 TFAP2A JASPAR yes 66994566 1206 70545055
chr15 66993351 66993671 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 895 108148428
chr15 66993352 66993367 NFYB JASPAR yes 66994566 1199 70545056
chr15 66993352 66993722 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 844 108148429
chr15 66993354 66993370 NFYA JASPAR yes 66994566 1196 70545057
chr15 66993355 66993373 NFYA JASPAR yes 66994566 1193 70545058
chr15 66993356 66993632 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 934 108148430
chr15 66993359 66993363 H1TF2 TRANSFAC yes 66994566 1203 70545059
chr15 66993359 66993363 NFE TRANSFAC yes 66994566 1203 70545060
chr15 66993359 66993363 SRF TRANSFAC yes 66994566 1203 70545061
chr15 66993362 66993732 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 834 108148431
chr15 66993382 66993838 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 728 108148432
chr15 66993387 66993396 TFAP4 TRANSFAC yes 66994566 1170 70545062
chr15 66993392 66993728 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 838 108148433
chr15 66993394 66993399 SP1 TRANSFAC yes 66994566 1167 70545063
chr15 66993406 66993415 THAP1 JASPAR yes 66994566 1151 70545064
chr15 66993410 66993746 TCF7L2 ENCODE Uniform TFBS no Pancreas (Panc1) 66994566 820 108148434
chr15 66993411 66993417 ETS1 JASPAR yes 66994566 1149 70545065
chr15 66993412 66993782 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 784 108148435
chr15 66993414 66993738 ZNF143 ENCODE Uniform TFBS no Embryonic Stem Cell Line (H1-hESC) 66994566 828 108148436
chr15 66993416 66993426 SP1 JASPAR yes 66994566 1140 70545066
chr15 66993417 66993425 SP1 TRANSFAC yes 66994566 1141 70545067
chr15 66993417 66993426 SP1 TRANSFAC yes 66994566 1140 70545068
chr15 66993418 66993423 SP1 TRANSFAC yes 66994566 1143 70545069
chr15 66993419 66993424 SP1 TRANSFAC yes 66994566 1142 70545070
chr15 66993419 66993425 SP1 TRANSFAC yes 66994566 1141 70545071
chr15 66993430 66993445 ZIC3 JASPAR yes 66994566 1121 70545072
chr15 66993435 66993445 SP1 JASPAR yes 66994566 1121 70545073
chr15 66993436 66993726 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 840 108148437
chr15 66993438 66993443 SP1 TRANSFAC yes 66994566 1123 70545074
chr15 66993439 66993739 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 827 108148438
chr15 66993441 66993446 SP1 TRANSFAC yes 66994566 1120 70545075
chr15 66993442 66993722 ZBTB33 ENCODE Uniform TFBS no Lung (A549) 66994566 844 108148439
chr15 66993449 66993709 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 857 108148440
chr15 66993455 66993470 NR2C2 JASPAR yes 66994566 1096 70545076
chr15 66993457 66993721 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 845 108148441
chr15 66993458 66993867 ZNF274 ENCODE Uniform TFBS no Bone Marrow (K562) 66994566 699 108148442
chr15 66993463 66993472 HiNF-C TRANSFAC yes 66994566 1094 70545077
chr15 66993463 66993473 SP1 JASPAR yes 66994566 1093 70545078
chr15 66993464 66993470 SP1 TRANSFAC yes 66994566 1096 70545079
chr15 66993464 66993678 ZBTB33 ENCODE Uniform TFBS no Colon (HCT116) 66994566 888 108148443
chr15 66993465 66993470 SP1 TRANSFAC yes 66994566 1096 70545080
chr15 66993466 66993471 SP1 TRANSFAC yes 66994566 1095 70545081
chr15 66993466 66993472 SP1 TRANSFAC yes 66994566 1094 70545082
chr15 66993469 66993474 SP1 TRANSFAC yes 66994566 1092 70545083
chr15 66993469 66993476 SP1 TRANSFAC yes 66994566 1090 70545084
chr15 66993483 66993498 NFYB JASPAR yes 66994566 1068 70545085
chr15 66993485 66993501 NFYA JASPAR yes 66994566 1065 70545086
chr15 66993486 66993504 NFYA JASPAR yes 66994566 1062 70545087
chr15 66993490 66993494 H1TF2 TRANSFAC yes 66994566 1072 70545088
chr15 66993490 66993494 NFE TRANSFAC yes 66994566 1072 70545089
chr15 66993490 66993494 SRF TRANSFAC yes 66994566 1072 70545090
chr15 66993502 66993517 ZIC3 JASPAR yes 66994566 1049 70545091
chr15 66993503 66993515 TFAP2A JASPAR yes 66994566 1051 70545092
chr15 66993503 66993515 TFAP2B JASPAR yes 66994566 1051 70545093
chr15 66993503 66993515 TFAP2C JASPAR yes 66994566 1051 70545094
chr15 66993503 66993516 TFAP2A JASPAR yes 66994566 1050 70545095
chr15 66993503 66993516 TFAP2B JASPAR yes 66994566 1050 70545096
chr15 66993503 66993516 TFAP2C JASPAR yes 66994566 1050 70545097
chr15 66993503 66993733 ZZZ3 ENCODE Uniform TFBS no Cervix (HeLa-S3) 66994566 833 108148444
chr15 66993504 66993513 TFAP2A JASPAR yes 66994566 1053 70545098
chr15 66993507 66993522 NR2C2 JASPAR yes 66994566 1044 70545099
chr15 66993508 66993518 SP1 JASPAR yes 66994566 1048 70545100
chr15 66993508 66993518 ZNF740 JASPAR yes 66994566 1048 70545101
chr15 66993508 66993522 PLAG1 JASPAR yes 66994566 1044 70545102
chr15 66993509 66993523 PLAG1 JASPAR yes 66994566 1043 70545103
chr15 66993510 66993520 SP1 JASPAR yes 66994566 1046 70545104
chr15 66993511 66993520 SP1 TRANSFAC yes 66994566 1046 70545105
chr15 66993511 66993521 SP1 JASPAR yes 66994566 1045 70545106
chr15 66993512 66993522 SP1 JASPAR yes 66994566 1044 70545107
chr15 66993513 66993519 MAZ TRANSFAC yes 66994566 1047 70545108
chr15 66993513 66993523 SP1 JASPAR yes 66994566 1043 70545109
chr15 66993519 66993524 SP1 TRANSFAC yes 66994566 1042 70545110
chr15 66993520 66993694 ZNF274 ENCODE Uniform TFBS no Liver (HepG2) 66994566 872 108148445
chr15 66993534 66993544 MZF1 JASPAR yes 66994566 1022 70545111
chr15 66993537 66993543 SP1 TRANSFAC yes 66994566 1023 70545112
chr15 66993548 66993566 NFYA JASPAR yes 66994566 1000 70545113
chr15 66993552 66993556 H1TF2 TRANSFAC yes 66994566 1010 70545114
chr15 66993552 66993556 NFE TRANSFAC yes 66994566 1010 70545115
chr15 66993552 66993556 SRF TRANSFAC yes 66994566 1010 70545116
SNPs associated with SMAD6[ENSG00000137834.10], confirmed by eQTL
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Chrom. Position dbSNP ID Reference Allele Alternative Allele Distance between TSS and SNP Tissue q Value id More
chr15 67395621 rs114214638 C T 321283 Esophagus 0.0364416 4043860
chr15 67402085 rs139603542 G A,C,T 327747 Esophagus 0.319972 4043962
chr15 67358478 rs1061427 G A 284140 Heart 0.122783 4043374
chr15 67835059 rs67999453 TCGCCGCTACCGCCGTCGCCGC T 760721 Pancreas 0.290576 4045767
chr15 67319369 rs149724023 G A 245031 Breast 0.214647 4042938
chr15 66455542 rs1477797 G A 539024 Ovary 0.147395 4035436
chr15 66535572 rs9652477 T C 458994 Uterus 0.26228 4036083
chr15 67487275 rs72661162 T C 412937 Liver 0.434749 4044814
chr15 66924801 rs4351998 A G 69765 Stomach 0.242912 4038215
chr15 66585907 rs75040294 C A 408659 Adrenal 0.311724 4036338
Details of SMAD6[ENSG00000137834.10]
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Genomic Location chr15:66994566-67074338[+]
TSS 66994566
Gene Name SMAD6
Ensembl ID ENSG00000137834.10
ENTREZID 4091
Uniprot
O43541
Protein Name
Alternative protein SMAD6
Mothers against decapentaplegic homolog 6
Expression levels of SMAD6[ENSG00000137834.10]
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