What is eccDNA Atlas?

   Extrachromosomal circular DNAs (eccDNAs) represent a large category of nonmitochondrial and nonplasmid circular extrachromosomal DNA playing an indispensable role involved in various aspects such as tumorigenesis, immune responses and biomarker, etc. However, characteristic and functions of eccDNAs/ecDNAs are fragmented, hide behind abundant literatures and large amounts of available whole-genome sequencing (WGS) data are unemployed for identification of eccDNAs. Therefore, an integrated repository portal through manually curating eccDNAs from literatures and identifying new eccDNAs from WGS data is essential to further research and understanding the mechanisms and functions of eccDNAs. Here, we developed eccDNA Atlas, a user-friendly database of eccDNAs that aims to provide a high-quality and integrated resource for browsing, searching and analyzing eccDNAs such as sequence, function/characteristic, validation strategies, etc. from multiple species. eccDNA Atlas currently containing 629,987 eccDNAs and 8,221 ecDNAs manually curated from literatures and 1,105 ecDNAs predicted by AmpliconArchitect based on WGS data involved in 66 diseases, 57 tissues and 319 cell lines. Furthermore, abundant annotations and analyzing utilities were provided to explore eccDNA Atlas eccDNAs or user-defined eccDNAs such as oncogenes, typical enhancers, super enhancers, gene expression, survival, genome visualization, etc.